{"id":3387,"date":"2022-12-16T07:19:12","date_gmt":"2022-12-16T07:19:12","guid":{"rendered":"https:\/\/katraps.eu\/?page_id=3387"},"modified":"2024-07-07T11:05:56","modified_gmt":"2024-07-07T09:05:56","slug":"bladder-cancer","status":"publish","type":"page","link":"https:\/\/spartakhadjiev.com\/en\/bladder-cancer\/","title":{"rendered":"BLADDER CANCER"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"3387\" class=\"elementor elementor-3387\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f4f21ec elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f4f21ec\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-abff327\" data-id=\"abff327\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4f57ada elementor-widget elementor-widget-heading\" data-id=\"4f57ada\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"><b>Bladder cancer<\/b><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-000a5a0 elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"000a5a0\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d5f6a02\" data-id=\"d5f6a02\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-74e4a95 elementor-widget elementor-widget-text-editor\" data-id=\"74e4a95\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"translation-block\">Bladder tumors rank second in frequency among genitourinary tumors. The disease occurs more often among men, with a gender ratio of 3:1. About two-thirds of those affected are registered over the age of 65. There is a difference in the incidence of the disease according to race and geographic location. A higher incidence is observed among Caucasians and highly industrialized countries. The incidence is the lowest among Asian countries. In 2012, 7,549 patients with bladder cancer were registered in Bulgaria, 1,144 new cases were registered, and 425 people died from the disease during the year. Follow-up shows a permanent trend towards an increase in bladder cancer cases, while the mortality rate does not show any significant changes .<\/p><h4><span data-contrast=\"auto\">Papilloma viruses<\/span><\/h4><p class=\"translation-block\">Papillomaviruses are again suspected as the causative agents of this type of cancer, which, considering the very common inflammatory diseases of the urinary bladder (cystitis), fits our inflammatory-microbial theory of the origin of cancer.<\/p><p class=\"translation-block\">A leading part of the international standards for the treatment of urothelial tumors is intravesical instillation with BCG in stages in situ and 1\/2a.<\/p><p class=\"translation-block\">Different strains of BCG and different preparations are used, usually containing a higher dose than the standard BCG ampoules for immunization against tuberculosis. The Bulgarian preparation KALGEVAX, for example, contains 11.25 mg, but 2-3 ampoules are administered weekly for 6 weeks and then monthly for 6-12 months after surgery.<\/p><p><span style=\"letter-spacing: 0px;\" data-contrast=\"auto\">In patients who have undergone intravesical BCG therapy, we wait at least 6 months before starting CATRAPS therapy to avoid any possibility of BCG accumulation in the body or of causing side effects from BCG instillations, which are well described above in the text.<\/span><span style=\"letter-spacing: 0px;\" data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:107,&quot;335559737&quot;:402,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p><p class=\"translation-block\">Papillomaviruses are again suspected as the causative agents of this type of cancer, which, considering the very common inflammatory diseases of the urinary bladder (cystitis), fits our inflammatory-microbial theory of the origin of cancer.<\/p><h4><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:107,&quot;335559731&quot;:566,&quot;335559737&quot;:451,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">Analysis of data from treatment with Catraps <\/span><\/h4><p><span style=\"letter-spacing: 0px;\" data-contrast=\"auto\">In our treatment, patients are not selected and it often happens that they are in stage 3-4, when they have undergone all types of \"standard\" therapy and after having undergone more than 3 - 5 or 8 TURs (trans-urethral resection of tumors in the bladder).<\/span><\/p><p><span data-contrast=\"auto\">\u00a0 \u00a0 \u00a0If we show over 3-year survival in the absence of recurrence, (recurrences are most common in the first year after Tu-TUR operation), the percentages become 57.5%. Our impressions of all our patients with this diagnosis is their almost 100% improvement, expressed in the absence of recurrence, proven by regular ultrasounds and much less often by cystoscopy<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:107,&quot;335559731&quot;:566,&quot;335559737&quot;:451,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">.<\/span><\/p><p class=\"translation-block\">Our patients live a wonderful quality of life, without the severe side effects of intravesical instillation. Ruthless global statistics show that smoking is a major risk factor for the formation of tumors in the bladder.<\/p><p><span style=\"letter-spacing: 0px;\" data-contrast=\"auto\">\u0412\u0441\u0435\u043a\u0438 \u0437\u043d\u0430\u0435 \u0437\u0430 \u0432\u0440\u0435\u0434\u0430\u0442\u0430 \u043e\u0442 \u0442\u044e\u0442\u044e\u043d\u043e\u043f\u0443\u0448\u0435\u043d\u0435\u0442\u043e \u0432\u044a\u0440\u0445\u0443 \u0443\u0441\u0442\u043d\u0430\u0442\u0430 \u043a\u0443\u0445\u0438\u043d\u0430, \u043b\u0430\u0440\u0438\u043d\u0433\u0441\u0430 \u0438 \u0431\u0435\u043b\u0438\u0442\u0435 \u0434\u0440\u043e\u0431\u043e\u0432\u0435 , \u043d\u043e \u0435 \u043f\u043e-\u043c\u0430\u043b\u043a\u043e \u0438\u0437\u0432\u0435\u0441\u0442\u0435\u043d \u0444\u0430\u043a\u0442 \u0435 \u0432\u044a\u0437\u0434\u0435\u0439\u0441\u0442\u0432\u0438\u0435\u0442\u043e \u043d\u0430 \u0442\u044e\u0442\u044e\u043d\u043e\u043f\u0443\u0448\u0435\u043d\u0435\u0442\u043e \u0432\u044a\u0440\u0445\u0443 \u043e\u0440\u0433\u0430\u043d\u0438\u0442\u0435 \u043d\u0430 \u043f\u0438\u043a\u043e\u0447\u043d\u0430\u0442\u0430 \u0441\u0438\u0441\u0442\u0435\u043c\u0430, \u0447\u0440\u0435\u0437 \u043a\u043e\u0438\u0442\u043e \u0441\u0442\u0430\u0432\u0430 \u0438\u0437\u043b\u044a\u0447\u0432\u0430\u043d\u0435\u0442\u043e \u043c\u0443 \u043e\u0442 \u043e\u0440\u0433\u0430\u043d\u0438\u0437\u043c\u0430 \u0442.\u0435. \u043f\u0438\u043a\u043e\u0447\u043d\u0438\u044f\u0442 \u043c\u0435\u0445\u0443\u0440 \u0438 \u0447\u0435\u0440\u0432\u0430\u0442\u0430. <\/span><span style=\"letter-spacing: 0px;\" data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559685&quot;:107,&quot;335559731&quot;:566,&quot;335559737&quot;:363,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p><p class=\"translation-block\">With the application of KATRAPS, the mechanism of action is similar, but it is even more strongly affected by the intradermal application of BCG, and thus the central organs of the immune system are engaged and together with the peripheral ones (in the bladder) provide a powerful cellular immune response with the destruction of cancer cells cells from your own body. And this happens without observing the unpleasant side effects of intravesical instillation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f580c62 elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f580c62\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-63386ec\" data-id=\"63386ec\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-aa4df6c elementor-widget elementor-widget-image\" data-id=\"aa4df6c\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"592\" src=\"https:\/\/spartakhadjiev.com\/wp-content\/uploads\/2023\/02\/bladder_graf_katraps-1024x592.png\" class=\"attachment-large size-large wp-image-4593\" alt=\"\" srcset=\"https:\/\/spartakhadjiev.com\/wp-content\/uploads\/2023\/02\/bladder_graf_katraps-1024x592.png 1024w, https:\/\/spartakhadjiev.com\/wp-content\/uploads\/2023\/02\/bladder_graf_katraps-300x173.png 300w, https:\/\/spartakhadjiev.com\/wp-content\/uploads\/2023\/02\/bladder_graf_katraps-768x444.png 768w, https:\/\/spartakhadjiev.com\/wp-content\/uploads\/2023\/02\/bladder_graf_katraps-600x347.png 600w, https:\/\/spartakhadjiev.com\/wp-content\/uploads\/2023\/02\/bladder_graf_katraps.webp 1458w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-aa3f23e elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"aa3f23e\" data-element_type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-74abfe0\" data-id=\"74abfe0\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-80237b2 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"80237b2\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5fee1c8 elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5fee1c8\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6ee43ba\" data-id=\"6ee43ba\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-6dfa9a6 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6dfa9a6\" data-element_type=\"section\" data-settings=\"{&quot;jet_parallax_layout_list&quot;:[]}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-852fffb\" data-id=\"852fffb\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d553b3a elementor-widget elementor-widget-text-editor\" data-id=\"d553b3a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"translation-block\">The diagram shows the proposed mechanism of action of BCG vaccine immunotherapy in bladder cancer. After local administration of a live BCG vaccine, the agent penetrates both healthy and diseased cells. This causes release of cytokines such as IL-6, IL-8, GM-CSF, TNF-\u03b1. The inflammatory response to these cytokines involves infiltration into the bladder of several types of immune cells: CD4+ and CD8+ lymphocytes, granulocytes, macrophages, and NK cells.<\/p><p><span data-contrast=\"auto\" style=\"letter-spacing: 0px;\">The cytotoxic effect of BCG therapy is due on the one hand to the vaccine itself, which suppresses proliferation and stops the cell cycle, and on the other hand to immune-mediated cytotoxicity, i.e. e.g. of the death ligand TRAIL (tumour necrosis factor-related apoptosis-inducing ligand) secreted by lymphocytes and NK cells.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-e97c9ff\" data-id=\"e97c9ff\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-88deabf elementor-widget elementor-widget-image\" data-id=\"88deabf\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"929\" height=\"587\" src=\"https:\/\/spartakhadjiev.com\/wp-content\/uploads\/2022\/12\/jpgraf-1.webp\" class=\"attachment-large size-large wp-image-3509\" alt=\"\" srcset=\"https:\/\/spartakhadjiev.com\/wp-content\/uploads\/2022\/12\/jpgraf-1.webp 929w, https:\/\/spartakhadjiev.com\/wp-content\/uploads\/2022\/12\/jpgraf-1-300x190.png 300w, https:\/\/spartakhadjiev.com\/wp-content\/uploads\/2022\/12\/jpgraf-1-768x485.png 768w, https:\/\/spartakhadjiev.com\/wp-content\/uploads\/2022\/12\/jpgraf-1-600x379.png 600w\" sizes=\"(max-width: 929px) 100vw, 929px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>\u0420\u0430\u043a \u043d\u0430 \u043f\u0438\u043a\u0443\u0447\u0435\u043d \u043c\u0435\u0445\u0443\u0440 \u00a0 \u00a0 \u00a0\u0422\u0443\u043c\u043e\u0440\u0438\u0442\u0435 \u043d\u0430 \u043f\u0438\u043a\u043e\u0447\u043d\u0438\u044f \u043c\u0435\u0445\u0443\u0440 \u0441\u0435 \u043d\u0430\u0440\u0435\u0436\u0434\u0430\u0442 \u043d\u0430 \u0432\u0442\u043e\u0440\u043e \u043c\u044f\u0441\u0442\u043e \u043f\u043e \u0447\u0435\u0441\u0442\u043e\u0442\u0430 \u0441\u0440\u0435\u0434 \u0442\u0443\u043c\u043e\u0440\u0438\u0442\u0435 \u043d\u0430 \u043f\u043e\u043b\u043e\u0432\u0430\u0442\u0430 \u0441\u0438\u0441\u0442\u0435\u043c\u0430. \u0417\u0430\u0431\u043e\u043b\u044f\u0432\u0430\u043d\u0435\u0442\u043e \u0441\u0435 \u0441\u0440\u0435\u0449\u0430 \u043f\u043e-\u0447\u0435\u0441\u0442\u043e \u0441\u0440\u0435\u0434 \u043c\u044a\u0436\u0435\u0442\u0435\u00a0 \u043a\u0430\u0442\u043e \u0441\u044a\u043e\u0442\u043d\u043e\u0448\u0435\u043d\u0438\u0435\u0442\u043e \u043f\u043e \u043f\u043e\u043b \u0435 3 : 1. \u041e\u043a\u043e\u043b\u043e \u0434\u0432\u0435 \u0442\u0440\u0435\u0442\u0438 \u043e\u0442 \u0437\u0430\u0431\u043e\u043b\u0435\u043b\u0438\u0442\u0435 \u0441\u0430 \u0440\u0435\u0433\u0438\u0441\u0442\u0440\u0438\u0440\u0430\u043d\u0438 \u0432\u044a\u0432 \u0432\u044a\u0437\u0440\u0430\u0441\u0442\u0442\u0430 \u043d\u0430\u0434 65 \u0433\u043e\u0434\u0438\u043d\u0438. \u041d\u0430\u0431\u043b\u044e\u0434\u0430\u0432\u0430 \u0441\u0435 \u0440\u0430\u0437\u043b\u0438\u0447\u0438\u0435 \u0432 \u0447\u0435\u0441\u0442\u043e\u0442\u0430\u0442\u0430 \u043d\u0430 \u0437\u0430\u0431\u043e\u043b\u044f\u0432\u0430\u043d\u0435\u0442\u043e [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ngg_post_thumbnail":0,"footnotes":""},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.5 - 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